Introduction from Drug peptide supply about:Lys-(Des-Arg9,Leu8)-Bradykinin,(Des-Arg10,Leu9)-Kallidin
| English name | Lys-(Des-Arg9,Leu8)-Bradykinin,(Des-Arg10,Leu9)-Kallidin |
| Chinese name | 缓激肽 |
| CAS NO | 71800-37-8 |
| Peptide sequence | Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu |
| Molecular formula | C47H75N13O11 |
| Molecular weight | 998.2 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms |
Biological activity of Lys-(Des-Arg9,Leu8)-Bradykinin,(Des-Arg10,Leu9)-Kallidin.
Bradykinin is a peptide chain containing nine amino acids. The amino acid sequence of bradykinin is Arg Pro Pro Gly He Ser Pro He Arg (RPPGFSPFR). Bradykinin is a peptide that causes vasodilation, which leads to a decrease in blood pressure. A class of drugs called ACE inhibitors used to lower blood pressure will increase the concentration of bradykinin (by inhibiting its degradation) and thus lower blood pressure. Bradykinin acts on blood vessels by releasing prostacyclin, nitric oxide and endothelium derived hyperpolarizing factor.
The use of Lys-(Des-Arg9,Leu8)-Bradykinin,(Des-Arg10,Leu9)-Kallidin.
As one of the terminal effectors of the kallikrein kinin system, bradykinin has a variety of biological activities, such as vasodilation, increasing vascular permeability, and inducing contraction of non vascular smooth muscle.
Lys-(Des-Arg9,Leu8)-Bradykinin,(Des-Arg10,Leu9)-Kallidin’s operating system
Bradykinin is a powerful endothelium-dependent vasodilator, which can lead to the contraction of non vascular smooth muscle, increase vascular permeability and also involve the mechanism of pain. Bradykinin also causes an increase in urine sodium, which helps lower blood pressure. Bradykinin will increase the level of calcium ions in astrocytes in the neocortex, causing them to release Chemalbook glutamate. In some patients who use angiotensin I converting enzyme (ACE) inhibitors, bradykinin is considered to be the cause of dry cough. This difficult to treat cough is usually caused by stopping the treatment of ACE inhibitors. In this case, angiotensin II receptor antagonists are used for further treatment.
How to buy Lys-(Des-Arg9,Leu8)-Bradykinin,(Des-Arg10,Leu9)-Kallidin in the U. S.
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