Detail introduction: Leuprorelin/Leuprorelin acetate/lupron/tap-144/53714-56-0/74381-53-6
| English name | Leuprorelin |
| CAS NO | 74381-53-6/53714-56-0 |
| Peptide sequence | Glp-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt |
| Molecular formula | C61H88N16O14 |
| Molecular weight | 1269.47 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Leuprorelin acetate;leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid;lupron;tap-144;Abbott43818;ProcrenDepot;Procrin;Prostap |
What is Leuprorelin?
Leuprorelin, also known as leuprolide, is a synthetic water-soluble nonapeptide with both ends blocked, with a molecular weight of 1269.47, soluble in water, ethanol and propylene glycol, and pKa6.9.
The application of Leuprorelin in medicine
Leuprorelin acetate is a commonly used hormone anti-malignant drug. It is the acetate salt of leuprolide, a nonapeptide synthetic analogue of gonadotropin-releasing hormone (LHRH, a decapeptide), belonging to LH-RH The antagonist, LHRH is produced by the hypothalamus, which can promote the release of gonadotropins and follicle stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland.
Because of its structure similar to LHRH, this product also has the function of promoting the release of FSH and LH after acting on the anterior pituitary, thereby increasing the serum concentration of testosterone and dihydrotestosterone.
It is clinically used for the maintenance treatment of advanced prostate cancer, but after applying this product for about 1 week, the number of active receptors will decrease, and the secretion of gonadotropins will also decrease. After 2 to 4 weeks, the concentration of testosterone and dihydrotestosterone can be reduced to castrate levels.
When the drug is stopped, gonadotropins and androgens can return to normal concentrations. It should be noted that this product is not effective when taken orally, and it is well absorbed by subcutaneous or intramuscular injection.
The T1/2 for parenteral administration is 3h. There is no accumulation in the body, and the excretion rates of the original drug and metabolites in the urine are 2.9% and 1.5%, respectively.
The main uses of Leuprorelin
Leuprolide is a synthetic nonapeptide that is an agonist of GnRHR and is used in a variety of clinical treatments, including prostate cancer, endometriosis, uterine leiomyoma, central precocious puberty, and in vitro fertilization.
How to buy Leuprorelin in the U. S.
Peptide supplier Remetide specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Leuprorelin Peptide.