Cosyntropin/Adrenocorticotropic Hormone Fragment 1-24 human/16960-16-0

Detail introduction: Cosyntropin/Adrenocorticotropic Hormone Fragment 1-24 human/16960-16-0

What is Cosyntropin?

Cosyntropin is a man-made form of a hormone called adrenocorticotropic hormone (ACTH). ACTH is a hormone that is normally produced by the pituitary gland in the brain. ACTH stimulates the adrenal glands to release the hormones cortisol and adrenaline. These hormones help your body respond to stress and also support many systems of the body including circulation, metabolism, immunity, and the nervous system.

Indications

Ticocotide has the same effect as ACTH. Therefore, its clinical application range is similar to that of adrenocorticotropic hormone. Because of the same medication indications, corticosteroids with stronger effects and fewer side effects are often used. Therefore, Ticocortide is currently only used for a few diseases such as Crohn’s disease or ulcerative colitis, and rheumatoid arthritis. Patients who have been treated with corticosteroids for a long time can use Ticocetide in combination to prevent adrenal atrophy. Ticocotide and corticotropin are also used for adrenal function tests. However, long-acting Ticocetide is generally not used as a standard adrenal cortex function test drug.

Pharmacokinetics

Ticocotide is a synthetic polypeptide composed of 24 amino acids. Its structure is the same as the first to 24th amino acids of ACTH. Intravenous administration can rapidly increase the blood cortisol level, and the intravenous drip should be continued when the blood cortisol concentration needs to be maintained. In an intramuscular injection, blood cortisol reached a peak 1 hour after injection. After that, the elevated cortisol can be maintained for about 24 hours.

Adverse reactions

Same as ACTH. Extensive use can cause water and sodium retention and high blood pressure, mental disorders, impaired glucose tolerance, protein consumption, osteoporosis, hypokalemia, menstrual abnormalities, pigmentation and acne. A small number of patients may have allergic reactions to ticocetide, but the incidence is less than that of ACTH.

Biological activity of Cosyntropin

Tetracosactide (INN) is an analog of adrenal cortex hormone (ACTH), which has the biological activity of stimulating the secretion of adrenal cortex hormone.

Chemical nature

This product is a synthetic 24-peptide corticotropin analog. The sequence of amino acids is the same as the 24 amino acids at the amino terminal of natural corticotropin (human, bovine, pig), and has the same physiological activity as natural ACTHm. The most prominent feature is that it does not produce an antibody reaction under normal circumstances, and has no serious side effects. It is especially suitable for patients with allergic reactions or ineffectiveness to natural porcine corticotropin.

The effect of 1ml of this product is equivalent to 100 units of natural corticotropin. This product is not effective when taken orally. The blood cortisol concentration increased rapidly after intravenous injection and disappeared from the blood for about 30 minutes. The blood concentration reaches the maximum value after intramuscular injection for 1 hour, and the effect can be maintained for more than 4 hours.

Usage of Cosyntropin

Cosyntropin is used to diagnose adrenal cortex insufficiency; it can also be used to treat rheumatism, rheumatoid arthritis, skin diseases and shock. Adverse reactions and contraindications: itching, flushing, urticaria, bronchospasm, and other allergic reactions are less than corticotropin. Occasionally, fainting, collapse. Long-term or excessive use can cause edema, high blood pressure, hypokalemia, pigmentation, and induced infections, etc. People who are allergic to natural corticotropin should be used with caution.

How to buy Cosyntropin in the U. S.

Remetide Peptide Supplier specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Cosyntropin Peptides.