Introduction from Drug peptide supply about:Chlorotoxin/163515-35-3
| English name | Chlorotoxin |
| Chinese name | 氯毒素 |
| CAS NO | 163515-35-3 |
| Peptide sequence | Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2(Cys1&Cys4,Cys2&Cys6,Cys3&Cys7,Cys5&Cys8 Bridges) |
| Molecular formula | C158H249N53O47S11 |
| Molecular weight | 3995.7 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | CLTX (EGYPTIAN SCORPION) |
Mechanism of Chlorotoxin
Chlorotoxin is a scorpion toxin polypeptide. Human brain astrocytoma produces a unique voltage-dependent chloride ion current (called GCC current, and its chloride ion channel is called GCC channel), which is in normal human cells (including normal nerve cells). This chloride current can be effectively inhibited by the Cl-channel inhibitor chlorotoxin and lead to changes in the reproduction rate of brain tumor cells. It is speculated that Cl-channels are involved in regulation of astrocytoma growth. Chlorotoxin-sensitive GCC currents persisted in implanted glioma cells but not in adjacent normal host glial cells. This unique chloride channel was confirmed to be unique to gliomas. The selective binding of chlorotoxin to this chloride channel provides an effective new avenue for the identification and treatment of gliomas. Chlorotoxin selectively binds to glioma cells, while normal human tissues, including brain, kidney, and intestine, are negative for chlorotoxin immunostaining.
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