Introduction from Drug peptide supplier about Enfuvirtide/159519-65-0
| English name | Enfuvirtide |
| Chinese name | 恩夫韦地 |
| CAS NO | 159519-65-0 |
| Peptide sequence | Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2 |
| Molecular formula | C204H301N51O64 |
| Molecular weight | 4491.92 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Enfuvirtide Acetate(T-20); Pentafuside; Enfuvirtide; Aids059486 |
What is Enfuvirtide?
Enfuvirtide is the first HIV fusion inhibitor registered and marketed in the United States in March 2003. It is the only FI currently on the market, but its success has opened up the possibility of using polypeptide drugs to control HIV- 1 A new frontier of infection for the treatment of chronic human immunodeficiency virus (HIV) infection in adults and children over 6 years of age. The disadvantage of enfuvirtide is that it is easy to develop drug resistance, and it must be injected intravenously twice a day. Most patients will have injection site reactions because of this, which increases the difficulty of long-term medication. Enfuvirtide is a synthetic polypeptide derived from a naturally occurring amino acid sequence in the HR2 domain of gp41. By mimicking the activity of the HR2 domain and competing for binding to the HR1 domain of gp41, it prevents the interaction between HR1 and HR2 and the formation of gp41. changes that prevent the virus from fusing with the host cell. Like most peptide drugs, enfuvirtide is less likely to experience metabolic drug-drug interactions.
Pharmacological effects of Enfuvirtide
This product is a synthetic peptide HIV fusion inhibitor, which can bind to the viral envelope glycoprotein to prevent the conformational change necessary for the fusion of the virus and the cell membrane, thereby inhibiting the replication of HIV-1. Enfuvirtide is derived from a naturally occurring amino acid sequence in the HR2 domain of gp41. By mimicking the activity of the HR2 domain and competing for binding to the HR1 domain of gp41, it prevents the interaction between HR1 and HR2 and changes in gp41 configuration, thereby preventing The virus fuses with the host cell.
How to buy Enfuvirtide in the U. S.
Remetide Peptide Supplier specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Enfuvirtide Peptides.
