Detail introduction: Abarelix/Plenaxis/183552-38-7
| English name | Abarelix |
| CAS NO | 183552-38-7 |
| Peptide sequence | Ac-D2Nal-DCpa-DPal-Ser-NMeTyr-DAsp-Leu-Lys(ipr)-Pro-DAla-NH2 |
| Molecular formula | C72H95ClN14O14 |
| Molecular weight | 1416.06 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | PPI-149;Abarelix Acetate;Plenaxis;R 3827 |
What is Abarelix?
Abarelix reduces the amount of testosterone produced in the body. Abarelix is used in the palliative treatment of advanced prostate cancer.
Abarelix application overview
Abarelix was developed by Praecis Pharma-ceuticals in the United States and was first launched in United States in January 2004. Abarelix is an anti-tumor drug that is currently the first storable gonadotropin releasing hormone antagonist formula approved. It is also the first new type of prostate cancer drug.
Abarelix mainly works by reducing testosterone levels and can improve efficacy. Another dose of Abalelix, abarelix depot, is being studied in patients with endometrial hyperplasia.
Abarelix has potentially serious adverse reactions and is approved for advanced symptomatic prostate cancer that is not suitable for treatment with luteinizing hormone-releasing hormone (LHRH) agonists and refuses surgical resection and has one or more of the following conditions (PCA) Palliative care. There are 10 amino acids in the main chain of Abaric, which are composed as follows: Ac-D-Nal1-D-Cpa2-D-Pal3-Ser4-N-Me-Tyr5-D-Asn6-Leu7-Lys(iPr)8-Pro9- D- Ala10-NH2.
Abarelix reduces the production of testosterone in the testes by directly inhibiting the secretion of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Because it directly inhibits the secretion of LH, the plasma testosterone concentration will not increase first and then decrease. Saturation binding The results of the study show that Abaric has a high affinity for rat pituitary LHRH receptors.
What is the role of abarelix in the body?
Abarelix is a polypeptide compound composed of ten natural and non-natural amino acid residues in a linear sequence. It has a role as a hormone antagonist and an antineoplastic agent.
Abarelix is used for:
Treating symptoms of advanced prostate cancer and certain conditions as determined by your doctor. Abarelix is a gonadotropin releasing-hormone (GnRH) antagonist. It works by reducing the amount of a hormone called testosterone. Testosterone is involved in the growth of most prostate cancers.
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Drug usage and dosage of Abarelix
For safety reasons, this product was approved with market restrictions. Only those who have certain qualifications and indicate that they have undertaken relevant obligations require a prescription from a doctor. The recommended medication regimen is 100 mg intramuscular injection of this product on the first 1, 15, and 29 days, and a course of treatment every 4 weeks. The plasma testosterone concentration was measured before the injection on the 29th day to determine the therapeutic effect and every 8 weeks thereafter.
How to buy Abarelix/PPI-149/Plenaxis In the U.S.
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