Introduction from Remetide Drug peptide supplier: Desmopressin/62357-86-2/16679-58-6/16789-98-3
| English name | Desmopressin |
| Chinese name | 去氨加压素 |
| CAS NO | 62357-86-2/16679-58-6/16789-98-3 |
| Peptide sequence | Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-DArg-Gly-NH2(Mpr1&Cys6 bridge） |
| Molecular formula | C48H74N14O17S2 |
| Molecular weight | 1183.31 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | 1-(3-mercaptopropanoicacid)-8-d-argininevasopressinmonoacetate,trih;demopressin acetate;DesMopressin(acetate3H2O);kw-8008;stimateinjection |
Desmopressin for diabetes insipidus
Medicated diabetes insipidus is primarily a water metabolism disorder characterized by excess urine output, polydipsia, hypoosmolarity, and hypernatremia. Partial or complete deficiency of vasopressin (central diabetes insipidus), or renal insufficiency of vasopressin (nephrogenic diabetes insipidus) can be onset. Clinically, diabetes insipidus is similar to primary polydipsia, a condition in which excessive water intake is caused by a malfunction of the regulatory mechanism or abnormal thirst. Contrary to primary polydipsia, the increase in water intake in patients with diabetes insipidus is a corresponding response to changes in osmotic pressure or blood volume. Desmopressin, lysinepressin, and vasopressin are three commonly used drugs for the treatment of diabetes insipidus in clinical practice.
Pharmacological effects of desmopressin
Desmopressin is structurally similar to the natural hormone arginine vasopressin. It acts on V1 receptors, constricts blood vessels, acts on V2 receptors, and produces an antidiuretic effect. Its antidiuretic effect is 400 times stronger than that of vasopressin, while its effect on the smooth muscle is weak and its blood pressure boosting effect is weak. After use, it can reduce urine excretion, increase urine osmotic pressure, and reduce plasma osmotic pressure, thereby reducing frequent urination and nocturia. This product is absorbed from the nasal mucosa, and the bioavailability is 10% to 20%. After oral administration, most of them are destroyed in the gastrointestinal tract, and the bioavailability is less than 0.5%, but large doses can produce therapeutic effects. Such as oral 0.1 ~ 0.2mg, can maintain 8 ~ 12 hours of anti-diuretic effect.
How to buy Desmopressin in the U. S.
Remetide Peptide Supplier specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Desmopressin Peptides.
Hot line:+19498788363
Wechat:americhina
Email:amin@remetide.com