Introduction from Drug peptide supply about: Goralatide/127103-11-1
| English name | Goralatide |
| Chinese name | 戈雷拉肽 |
| CAS NO | 127103-11-1 |
| Peptide sequence | Ac-Ser-Asp-Lys-Pro |
| Molecular formula | C20H33N5O9 |
| Molecular weight | 487.5 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | REF DUPL |
Introduction of Goralatide
Goralatide is also called N-acetyl-serine-aspartic acid-lysine-proline (N-Acetyl-Ser-Asp-Lys-Pro), abbreviated as Ac-SDKP, which is nitrogen-terminal Acetylated endogenous tetrapeptides are widely distributed in various tissues and body fluids in the body. This tetrapeptide is primarily released from its precursor thymosin β4 via prolyl oligopeptidase (POP) hydrolysis. Concentrations in the blood are generally in the nanomolar range.
Biological Activity of Goralatide
Goralatide is a multifunctional physiological regulator with multiple biological activities. It has been reported earlier that Goralatide can inhibit the activity of hematopoietic stem cells by preventing the primitive hematopoietic stem cells from entering the S phase and making them quiescent in the G0 phase. Goralatide was subsequently found to enhance the replantation capacity of the epidermis by promoting angiogenesis and accelerating wound healing in damaged avascular epidermal grafts. Goralatidecan inhibits the differentiation of MGM-stimulated bone marrow stem cells into macrophages, thereby exerting an anti-inflammatory effect. Goralatide has recently been found to have an inhibitory effect on the proliferation of various cells.
Pharmacokinetics of Goralatide
The pharmacokinetic study of Goralatide found that after intravenous injection of Goralatide into the body, it was quickly degraded, with a half-life of only 4 to 5 minutes. Goralatide is cleared from plasma in humans by two mechanisms:
① angiotensin-converting enzyme (ACE)-mediated hydrolysis;
② glomerular filtration. Among them, angiotensin-converting enzyme (ACE)-mediated hydrolysis is the main pathway of Goralatide metabolism.
How to buy Goralatide in the U. S.
Remetide Peptide Supplier specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact Remetide if you have any questions or inquiries about Goralatide Peptides.
Hot line:+19498788363
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Email:amin@remetide.com