Introduction from Drug peptide supply about: Linaclotide/851199-59-2
| English name | Linaclotide |
| Chinese name | 利那洛肽 |
| CAS NO | 851199-59-2 |
| Peptide sequence | Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr |
| Molecular formula | C59H79N15O21S6 |
| Molecular weight | 1526.8 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Linaclotide Acetate; CY-14 |
What is linaclotide?
Linaclotide is used to treat chronic constipation or chronic irritable bowel syndrome (IBS) in people who have had constipation as the main symptom.
The mechanism of action of linaclotide
Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolites can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.
Applications of Linaclotide
For the treatment of constipated irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).
How to buy Linaclotide in the U. S.
Remetide Peptide Supplier specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Linaclotide Peptides.
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