Introduction from Drug peptide supplier about Octreotide/79517-01-4
| English name | Octreotide |
| Chinese name | 奥曲肽 |
| CAS NO | 79517-01-4 |
| Peptide sequence | DPhe-Cys-Phe-DTrp-Lys-Thr-Cys-Thr-ol(Cys2&Cys7 bridge) |
| Molecular formula | C51H70N10O12S2 |
| Molecular weight | 1079.3 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | SANDOSTATIN;SMS-201-995；cyclic(2-7)-disulfide,(r-l-threonyl-n-(2-hydroxy-1-(hydroxymethyl)propyl); |
What is Octreotide?
Octreotide is a digestive system drug, a synthetic octapeptide cyclic compound, a homologue of natural somatostatin. It has the pharmacological activity of natural somatostatin (Somatostatin), and a long-term effect (the half-life of this product is 1.5 hours versus 2 to 3 minutes for native somatostatin). This product has a selective inhibitory effect on the secretion of growth hormone, glucagon, and insulin, which is stronger than natural somatostatin. It has been proved by animal experiments that when this product is injected intravenously for 15 minutes, the inhibitory effect on the release of growth hormone is natural growth. 70 times that of statin, the inhibition of insulin is 3 times that of natural somatostatin. It also has inhibitory effects on thyrotropin, adrenocorticotropic hormone, gastrin, cholecystokinin, and intestinal vasoactive polypeptide, and can inhibit the secretion of gastric acid, pancreatic amylase, lipase and pepsin. It can slow down the transit time of the gastrointestinal tract, promote the absorption of water and electrolytes, have a constricting effect on splanchnic blood vessels, can reduce splanchnic blood flow, reduce liver blood flow, reduce portal pressure and portal blood flow, and reduce intestinal excess. secretion, and can enhance intestinal absorption of water and Na+.
Main applications of octreotide
In clinical practice, octreotide is mainly used to treat esophageal varices caused by portal hypertension, acromegaly, gastrointestinal bleeding such as liver cirrhosis, esophageal varices bleeding, peptic ulcer bleeding and stress ulcer bleeding, pancreatic diseases such as Severe acute pancreatitis, pancreatic injury or postoperative pancreatic fistula, and prevention of postoperative complications of pancreatic surgery. Also used for gastrointestinal fistulas, endocrine tumors of the digestive system such as intestinal vasoactive peptide tumors, gastrinomas, glucagonomas, ectopic ACTH syndrome, carcinoid syndrome, acromegaly, exophthalmos, hyperthyroidism Symptoms, persistent, intractable diarrhea and AIDS-related diarrhea after total colectomy. Intrathecal injections are used to treat cancer pain.
Biological Activity of Octreotide
Octreotide is a long-acting synthetic analog of natural somatostatin and is a more potent inhibitor of growth hormone, glucagon and insulin than somatostatin.
How to buy Octreotide in the U. S.
Remetide Peptide Supplier specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Octreotide Peptides.
Hot line:+19498788363
Wechat:americhina
Email:amin@remetide.com