Introduction from Drug peptide supply about: PROTIRELIN
| English name | PROTIRELIN |
| Chinese name | 普罗瑞林 |
| CAS NO | 24305-27-9 |
| Peptide sequence | Glp-His-Pro-NH2 |
| Molecular formula | C16H22N6O4 |
| Molecular weight | 362.38 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | THR 1-2; THR 2-3; PROTIRELIN; PYROGLU-HIS-PRO AMIDE |
What is Protirelin?
Protirelin, formerly known as Thyrotropin-releasing hormone, is a tripeptide hormone released by the hypothalamus. In the late 1960s, it was first purified and synthesized from the hypothalamic tissue of sheep and pigs. TRH is widely distributed in the central nervous system and some peripheral organs. In addition to its endocrine effect, it also acts as an endogenous excitatory neurotransmitter, which can produce a wide range of central and peripheral effects. It has a certain effect of antagonizing endogenous opioid receptors, but it does not antagonize the analgesic effect of morphine. Protirelin was first disclosed to have an anti-shock effect.
Pharmacological effects of protirelin
Experiments have shown that protirelin does not have naloxone to fully antagonize the analgesic, addiction, braking, respiratory depression and lethal effects of morphine drugs. In the isolated guinea pig ileum experiment, different from naloxone, protirelin did not antagonize DHE to inhibit the contraction of guinea pig ileum, and the concentration-response curve shifted slightly to the left. Therefore, protirelin is superior to naloxone for war-traumatic shock. Blood pressure increased slightly while breathing deepened and accelerated, and gastrointestinal motility increased, but heart rate had little effect. Protirelin does not antagonize the analgesic effect of morphine but has a certain excitatory effect on the respiratory, circulatory and central nervous systems of normal animals.
Other Applications of Protirelin
In addition to the treatment of shock, Promorelin has other uses, such as the treatment of hypothalamic hypothyroidism and central hyperthyroidism in endocrinology. Psychiatry is used to treat depression and schizophrenia. Neurology is used for the treatment of brain and spinal cord injury, coma for various reasons, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile dementia, epilepsy, etc. Diagnosis is used for the diagnosis of hyperthyroidism. Therefore, protirelin is a drug with good development value and worthy of further research to expand the scope of application.
How to buy Protirelin in the U. S.
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