Detail introduction: Sincalide/25126-32-3
| English name | Sincalide |
| Chinese name | 辛卡利特 |
| CAS NO | 25126-32-3 |
| Peptide sequence | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 |
| Molecular formula | C49H62N10O16S3 |
| Molecular weight | 1143.27 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | PANCREOZYMINC-TERMINALOCTAPEPTIDE;
(Tyr[SO3H]27)Cholecystokininfragment26-33Amide; [27-TYR(SO3H)]CHOLECYSTOKININ-FRAGMENT(26-33)-AMIDE |
Introduction of Sincalide
Sincalide is an octapeptide molecule, which is a fragment of cholecystokinin. Cholecystokinin (CCK) is a brain-gut peptide with multiple molecular forms and dual distribution. It is composed of 33 amino acids. Has the role of hormones and neurotransmitters. With all the biological activities of cholecystokinin, it is a synthetic cholecystokinin octapeptide (Octapeptide),
What are the main applications of Sincalide?
Sincalide is used to promote gallbladder contraction to cooperate and strengthen secretin for the examination of pancreatic exocrine function; CCK is used to replace fatty meal during cholecystography, which can promote bowel movement and shorten the time of barium meal examination. It can also be used to treat intestinal paralysis. It is clinically used to treat chronic pancreatitis, and it is found that the pancreatic secretion function is significantly improved, and the symptoms are significantly reduced.
Sincalide preparation methods
It mainly solves the technical problems that the reagents in the existing enzymatic preparation are difficult to remove and the product performance of the chemical method is unstable and the yield is not ideal. The method includes the following steps:
1) The crude peptide obtained by solid phase synthesis is fully dissolved in ammonia water and passed through an ultrafiltration column;
2) Connect the ultrafiltration column and the high-pressure single pump, and select acetic acid water as the eluent to obtain the crude it intermediate liquid without the TFA salt;
3) Adjust the pH to 7.25 with NH4HCO3 solution for the crude it intermediate liquid from which the TFA salt has been removed;
4) Purify the crude sincalide intermediate liquid with a reversed-phase silica gel column with octadecylsilane-bonded silica gel as the stationary phase, and the mobile phase for phase A 0.2% acetic acid aqueous solution and phase B acetonitrile solution to obtain high-purity vinegar. it liquid in the form of an acid salt;
5) The obtained liquid in the form of acetate is concentrated and freeze-dried, and finally solid it with a content of more than 98.5% is obtained.
How to buy Sincalide Peptide in the U. S.
Peptide supplier Remetide specializes in the production and sales of peptides in the USA, as well as Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Sincalide Peptides.