Introduction from Drug peptide supply about: Teriparatide/99294-94-7/52232-67-4
| English name | Teriparatide |
| Chinese name | 特立帕肽 |
| CAS NO | 99294-94-7/52232-67-4 |
| Peptide sequence | Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe |
| Molecular formula | C172H278N52O47S2 |
| Molecular weight | 3890.49792 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Teriparatide acetate; PARATHYROID HORMONE HUMAN; FRAGMENT 1-34; PTH (1-34) (HUMAN) |
What is Teriparatide?
Teriparatide is a synthetic 34-peptide, a 1-34 amino acid fragment of human parathyroid hormone PTH, which is the biologically active N-terminal region of endogenous parathyroid hormone PTH containing 84 amino acids. The immunological and biological properties of this product are exactly the same as those of endogenous parathyroid hormone PTH and bovine parathyroid hormone PTH (bPTH).
The mechanism of action of Teriparatide
Teriparatide can mediate bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells, and enhancing osteoblast differentiation. Intermittently stimulates the PHT-I receptor on the surface of osteoblasts, bone lining cells and bone marrow stromal cells by regulating the adenylate cyclase-cyclic adenosine monophosphate-protein kinase A pathway to promote osteoblast differentiation and prolong osteogenesis Cell lifespan; stimulates the proliferation of osteoblasts through the phosphate C-cytoplasmic calcium-protein kinase C signaling pathway; reduces the differentiation of stromal cells to adipocytes by inhibiting the transactivation activity of PPARγ, increasing the number of osteoblasts Increase; indirectly regulate bone growth by regulating cytokines, for example, iGF-1 can be induced to combine with osteoblasts, thereby promoting bone formation; regulating the process of bone formation through Wnt signaling pathway, thereby increasing bone formation.
Application of Teriparatide Drugs
Teriparatide was first approved for osteoporosis in postmenopausal women, and in men with primary or hypogonadal osteoporosis, and was later added with new indications for treatment with persistent, systemic Osteoporosis associated with glucocorticoid therapy.
How to buy Teriparatide in the U. S.
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