Introduction from Drug peptide supply about: Terlipressin/14636-12-5
| English name | Terlipressin |
| Chinese name | 特利加压素 |
| CAS NO | 14636-12-5 |
| Peptide sequence | Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2(Cys4&Cys9 bridge) |
| Molecular formula | C52H74N16O15S2 |
| Molecular weight | 1227.37 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressinum |
What is Terlipressin?
Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
Pharmacological effects of terlipressin
Terlipressin is a new type of synthetic long-acting vasopressin preparation, which belongs to a kind of prodrug and is inactive by itself. It is acted by aminopeptidase in vivo to remove three glycines from its N-terminus. After the acyl residue, the active lysine vasopressin is slowly “released”. It is this “slow release” mechanism that enables smooth muscle contractions to be maintained for up to 10 hours after a single dose, while the same dose of vasopressin can only maintain its activity for 20-40 minutes. On the other hand, due to the slow rate of enzymatic hydrolysis, the circulating lysine vasopressin cannot reach the toxic level, so the use of terlipressin is relatively safe. The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome.
Main applications of terlipressin
Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.
How to buy Terlipressin in the U. S.
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