Introduction from Drug peptide supply about:AF 12198
| English name | AF 12198 |
| Chinese name | |
| CAS NO | 185413-30-3 |
| Peptide sequence | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2 |
| Molecular formula | C96H123N19O22 |
| Molecular weight | 1895.1 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms |
Biological activity of AF 12198.
AF12198 is an effective, selective and specific peptide antagonist against human type I interleukin-1 receptor (IL1R1) (IC50=8nM), but not against human type II receptor (IC50=6.7 µ M) or mouse type I receptor (IC50>200 µ M). AChemicalbookF12198 inhibited IL-1 induced IL-8 production (IC50=25nM) and IL-1 induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9nM). AF12198 has anti-inflammatory activity and blocks the reaction to IL-1 in vivo.
How to buy AF 12198 in the U. S.
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