Introduction about 5-amino-1-methylquinolin-1-ium iodide/NNMTi
| English name | 5-amino-1-methylquinolin-1-ium iodide |
| Supplier | Remetide |
| CAS NO | 42464-96-0 |
| Sequence | |
| Molecular formula | |
| Molecular weight | |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | NNMTi |
Biological activity of NNMTi
NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) (IC50=1.2μM), 5-amino-1-methyl quinoline-1-ium iodide can selectively bind to the NNMT substrate-binding site Residues.
NNMTi can promote the differentiation of myoblasts in vitro and enhance the ability of fusion and regeneration of muscle stem cells in aged mice.
In vitro studies
NNMTi(10-30µM;96hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation.30µMNNMTiresultsin18%MHC positive Chemicalbookemyotubenuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts(12%MHC-positive myotube nuclei).
In vivo studies
NNMTi(subcutaneous(SC)injection; 5mg/kgand10mg/kg; 2weeks hasaneffectonmuscleregenerationafterinjury, itresultsin 60% and 75%
higherincidenceofproliferating/activemuSCsat5mg/kgand10mg/kg,respectively.TherelativenumbersoffiberswithanEdU+myonucleusincreased40%and48%withNNMTitreatmentat5mg/kgand10mg/kg
respectively.TheoddsratiooffusedmyonucleiforcontrolarChemicalbooke0.58and0.53timestheoddsatthelowandhighNNMTidose,respectively.