The Chemical structure of 5-amino-1-methylquinolin-1-ium

5-amino-1-methylquinolin-1-ium iodide/NNMTi

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Introduction about 5-amino-1-methylquinolin-1-ium iodide/NNMTi

Chemical formula of 5-amino-1-methylquinolin-1-ium iodide
The chemical formula of 5-amino-1-methylquinolin-1-ium iodide
English name 5-amino-1-methylquinolin-1-ium iodide
Supplier Remetide
CAS NO 42464-96-0
Molecular formula
Molecular weight
storage temperature 2-8℃
purity ≥98%
Package 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement.
Product English synonyms NNMTi

Biological activity of NNMTi

NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) (IC50=1.2μM), 5-amino-1-methyl quinoline-1-ium iodide can selectively bind to the NNMT substrate-binding site Residues.

NNMTi can promote the differentiation of myoblasts in vitro and enhance the ability of fusion and regeneration of muscle stem cells in aged mice.

In vitro studies

NNMTi(10-30µM;96hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation.30µMNNMTiresultsin18%MHC positive Chemicalbookemyotubenuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts(12%MHC-positive myotube nuclei).

In vivo studies

NNMTi(subcutaneous(SC)injection; 5mg/kgand10mg/kg; 2weeks hasaneffectonmuscleregenerationafterinjury, itresultsin 60% and 75%